First Time User? Sign Up Now
First Time User? Enroll now.
Home > Fitness & Health > Health Library > Addison's disease
Addison's disease is a rare condition that develops when the adrenal glands, located above the kidneys, are not able to produce enough of the hormones cortisol and aldosterone.
The adrenal glands release cortisol to help the body cope with stress from illness, injury, surgery, childbirth, or other reasons. Aldosterone helps the body retain salt and maintain blood pressure. Adrenal gland failure can be caused by a problem with the body's immune system (autoimmune disease) or by infection, tumor, bleeding, or injury.
Symptoms of Addison's disease include weakness, weight loss, nausea, vomiting, diarrhea, darkening of the skin (called hyperpigmentation), emotional distress, and a decreased ability to tolerate cold.
People who have Addison's disease need to take medicine for the rest of their lives to replace cortisol and aldosterone. Treatment relieves symptoms and usually reverses any darkening of the skin. After proper treatment is started, most people with Addison's disease can lead healthy lives. If Addison's disease is not treated, an adrenal crisis may occur that can lead to death because of a severe drop in blood pressure.
Current as of: July 29, 2019
Author: Healthwise Staff
Medical Review:Adam Husney MD - Family Medicine & E. Gregory Thompson MD - Internal Medicine & Kathleen Romito MD - Family Medicine & David C.W. Lau MD, PhD, FRCPC - Endocrinology
To learn more about Healthwise, visit Healthwise.org.
© 1995-2020 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Feeling under the weather?
Use our interactive symptom checker to evaluate your symptoms and determine appropriate action or treatment.
Our interactive Decision Points guide you through making key health decisions by combining medical information with your personal information.
You'll find Decision Points to help you answer questions about:
Get started learning more about your health!
Our Interactive Tools can help you make smart decisions for a healthier life. You'll find personal calculators and tools for health and fitness, lifestyle checkups, and pregnancy.