Alert

cobicistat

Pronunciation: koe BIK i stat

Brand: Tybost

What is the most important information I should know about cobicistat?

Cobicistat is not a complete treatment and must be used in combination only with atazanavir or darunavir.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with cobicistat and cause dangerous effects that could lead to death.

What is cobicistat?

Cobicistat is used to increase your blood levels of these medicines, helping to make them safer and more effective at lower doses.

Cobicistat is given together with atazanavir (Reyataz) or darunavir (Prezista) to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

When given with atazanavir, cobicistat is for use in adults and in children who weigh at least 77 pounds (35 kilograms). When given with darunavir, cobicistat is for use only in adults.

Cobicistat is not an antiviral medicine and will not treat HIV or AIDS. Cobicistat is given only to help increase your blood levels of atazanavir or darunavir.

Cobicistat may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking cobicistat?

Cobicistat is not a complete treatment and must be used in combination only with atazanavir or darunavir. You should not take cobicistat with any other antiviral medicines that your doctor has not prescribed.

You should not take cobicistat if you are allergic to it.

Many drugs can interact and cause dangerous effects that could lead to death. Some drugs should not be used together.

You should not take cobicistat with atazanavir if you also take:

  • indinavir;
  • irinotecan;
  • nevirapine; or
  • birth control pills that contain drospirenone and ethinyl estradiol (Beyaz, Sayfral, Yasmin, Yaz).

You should not take cobicistat with atazanavir or darunavir if you also take:

  • alfuzosin;
  • cisapride;
  • colchicine;
  • dronedarone;
  • oral midazolam, or triazolam;
  • ranolazine;
  • rifampin;
  • sildenafil (Revatio, for treating pulmonary arterial hypertension);
  • St. John's wort;
  • antipsychotic medicine --lurasidone, pimozide;
  • cholesterol medication --lomitapide, lovastatin, simvastatin;
  • ergot medicine --dihydroergotamine, ergotamine, methylergonovine; or
  • seizure medication --carbamazepine, phenobarbital, phenytoin.

You may not be able to take cobicistat if you also take:

  • darunavir 600 milligrams twice daily; or
  • certain other antiviral medicines --fosamprenavir, saquinavir, or tipranavir.

Tell your doctor if you have ever had:

  • liver disease; or
  • kidney disease, especially if you also take tenofovir.

You should not take this medicine if you are pregnant. Cobicistat or your other medicines may not work as well during pregnancy. Your doctor may prescribe different antiviral medications if you become pregnant while taking cobicistat.

Use your medications properly to control your infection during pregnancy. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take cobicistat?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Cobicistat is usually taken once per day with atazanavir or darunavir.

Take your HIV medicines with food at the same time each day to be sure you do not miss a dose.

If you take cobicistat with atazanavir and you also take medicine to reduce stomach acid, follow these recommendations unless your doctor tells you otherwise:

  • If you take an antacid, take it at least 2 hours before or 2 hours after you take cobicistat and atazanavir.
  • If you take a medicine such as cimetidine, ranitidine, Tagamet, Axid, Zantac, Pepcid, and others: Take the stomach medicine at the same time you take cobicistat and atazanavir; or wait at least 10 hours after taking the stomach medicine to take your cobicistat and atazanavir doses.
  • If you take a proton pump inhibitor such as omeprazole, esomeprazole, Nexium, Prevacid, Prilosec, Protonix: Wait at least 12 hours after taking the stomach medicine to take your cobicistat and atazanavir doses.

While using cobicistat, your blood may need to be tested often. Your kidney function may also need to be tested.

Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

Store in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking cobicistat?

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of cobicistat?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • kidney problems --little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
  • liver problems --upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea;
  • jaundice; or
  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cobicistat?

When you start or stop taking cobicistat, your doctor may need to adjust the doses of any other medicines you take on a regular basis.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current antiviral medicines.

Many drugs can affect cobicistat, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about cobicistat.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2020 Cerner Multum, Inc. Version: 3.01. Revision date: 9/10/2019.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.

Symptom Checker

Feeling under the weather?

Healthwise Symptom Checker Logo

Use our interactive symptom checker to evaluate your symptoms and determine appropriate action or treatment.

Decision Points

Our interactive Decision Points guide you through making key health decisions by combining medical information with your personal information.

You'll find Decision Points to help you answer questions about:

Interactive Tools

Get started learning more about your health!

Our Interactive Tools can help you make smart decisions for a healthier life. You'll find personal calculators and tools for health and fitness, lifestyle checkups, and pregnancy.