atovaquone and proguanil

Pronunciation: a TOE va kwone and pro GWAHN il

Brand: Malarone, Malarone Pediatric


slide 1 of 5, Malarone,

250 mg-100 mg, round, pink, imprinted with GXCM3

Image of Malarone
slide 1 of 5

Malarone Pediatric

slide 2 of 5, Malarone Pediatric,

62.5 mg-25 mg, round, pink, imprinted with GX CG7

Image of Malarone Pediatric
slide 2 of 5

Atovaquone-Proguanil Hydrochloride

slide 3 of 5, Atovaquone-Proguanil Hydrochloride,

250 mg-100 mg, round, pink, imprinted with GX CM3

Image of Atovaquone-Proguanil Hydrochloride
slide 3 of 5

Atovaquone-Proguanil Hydrochloride

slide 4 of 5, Atovaquone-Proguanil Hydrochloride,

250 mg-100 mg, round, pink, imprinted with 404, G

Image of Atovaquone-Proguanil Hydrochloride
slide 4 of 5


slide 5 of 5, Malarone,

250 mg-100 mg, round, pink, imprinted with GXCM3

Image of Malarone
slide 5 of 5

What is the most important information I should know about atovaquone and proguanil?

You should not use this medicine to prevent malaria if you have severe kidney disease.

What is atovaquone and proguanil?

Atovaquone and proguanil is a combination medicine used to treat or prevent malaria, a disease caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body.

Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

Atovaquone and proguanil may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking atovaquone and proguanil?

You should not use this medicine if you are allergic to atovaquone or proguanil.

Do not use atovaquone and proguanil to prevent malaria if you have severe kidney disease.

Atovaquone and proguanil should not be used to treat malaria in a child who weighs less than 11 pounds (5 kilograms), and should not be used to prevent malaria in a child who weighs less than 24 pounds (11 kilograms).

Tell your doctor if you have ever had:

  • kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Malaria is more likely to cause death in a pregnant woman. If you are pregnant, talk with your doctor about the risks of traveling to areas where malaria is common.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

How should I take atovaquone and proguanil?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take the medicine at the same time each day.

Take this medicine with food or milk if it upsets your stomach.

If you vomit within 1 hour after taking this medication, take another dose.

If you are take this medicine to prevent malaria:

  • Start taking the medicine 1 or 2 days before entering an area where malaria is common. Continue taking the medicine every day during your stay and for at least 7 days after you leave the area.

Use atovaquone and proguanil regularly to best prevent malaria. If you stop using the medication early for any reason, talk to your doctor about other forms of malaria prevention.

If you take this medicine to treat malaria:

  • Take the medicine every day for 3 days in a row.
  • Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

Use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.

Call your doctor as soon as possible if you have been exposed to malaria, or if you have fever, vomiting, or diarrhea during or after a stay in an area where malaria is common.

No medication is 100% effective in treating or preventing all types of malaria. For best results, keep using the medication as directed.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include stomach discomfort, vomiting, mouth sores, hair loss, easy bruising or bleeding, and peeling of the skin on your hands or feet.

What should I avoid while taking atovaquone and proguanil?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of atovaquone and proguanil?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • stomach pain (upper right side), loss of appetite;
  • tiredness, itching;
  • dark urine, clay-colored stools; or
  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • stomach pain, vomiting, diarrhea;
  • mouth sores;
  • headache, dizziness, weakness;
  • strange dreams;
  • itching; or
  • cough

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect atovaquone and proguanil?

Tell your doctor about all other medicines you use, especially:

  • metoclopramide;
  • rifabutin;
  • rifampin;
  • tetracycline; or
  • a blood thinner --warfarin, Coumadin, Jantoven.

This list is not complete. Other drugs may affect atovaquone and proguanil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about atovaquone and proguanil.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2022 Cerner Multum, Inc. Version: 6.01. Revision date: 11/20/2018.

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