Alert

interferon beta-1a

Pronunciation: in ter FEAR on BAY ta

Brand: Avonex, Rebif

What is the most important information I should know about interferon beta-1a?

Interferon beta-1a can harm your liver. Call your doctor if you have symptoms such as nausea, loss of appetite, tiredness, confusion, easy bruising or bleeding, dark urine, clay-colored stools, or yellowing of your skin or eyes.

Some people have thoughts about suicide while using interferon beta-1a. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What is interferon beta-1a?

Interferon beta-1a is used to treat relapsing multiple sclerosis (MS) in adults.

This medicine will not cure MS, it will only decrease the frequency of relapse symptoms.

Interferon beta-1a may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using interferon beta-1a?

You should not use this medicine if you are allergic to interferon beta or human albumin.

Tell your doctor if you have ever had:

  • depression, mental illness, or suicidal thoughts or actions;
  • liver disease;
  • bleeding problems;
  • low blood cell counts;
  • heart disease;
  • a thyroid disorder;
  • a latex allergy;
  • an autoimmune disorder such as rheumatoid arthritis, lupus, or psoriasis;
  • a seizure; or
  • if you drink alcohol.

Some brands of interferon beta-1a contain donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I use interferon beta-1a?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Interferon beta-1a is given by injection. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Avonex is injected into a muscle, usually once weekly at bedtime, on the same day each week (such as every Monday).

Rebif is injected under the skin, usually 3 times per week (such as Monday, Wednesday, and Friday) at the same time on each dosing day.

The powder form of this medicine must be mixed with a liquid (diluent) before using it. Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Your care provider will show you where on your body to inject interferon beta-1a. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

About 2 hours after your injection, check for skin redness, swelling, or pain where you gave the injection. Call your doctor if you have a skin reaction that does not go away within a few days.

This medicine can cause flu-like symptoms, especially when you first start using it. You may be given other medications to help prevent these symptoms. Keep using these medicines for as long as your doctor has prescribed.

You will need frequent medical tests.

Each prefilled syringe or injection pen is for one use only. Throw it away after one use, even if there is still medicine left inside.

Store this medicine in the refrigerator. Protect from light and do not freeze.

After mixing the powder form of interferon beta-1a with a diluent, store the mixture in a refrigerator and use it within 6 hours.

The Avonex prefilled syringe or autoinjector may be removed from the refrigerator about 30 minutes before your injection, to reach room temperature. Do not warm the medicine under hot water.

You may also store interferon beta-1a for a short time at cool room temperature protected from light.

  • Do not leave the Avonex prefilled syringe or autoinjector out of a refrigerator for longer than 7 days.
  • Do not leave the Avonex vial or the Rebif prefilled syringe or autoinjector out of a refrigerator for longer than a total of 30 days.

Do not freeze interferon beta-1a, and throw away the medicine if it has become frozen.

Each vial, syringe, or autoinjector is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

For Avonex: Use the medicine as soon as you can, but do not inject Avonex two days in a row. Do not use two doses at one time.

For Rebif: Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using interferon beta-1a?

Avoid injecting this medicine into skin that is red, bruised, irritated, scarred, or infected.

What are the possible side effects of interferon beta-1a?

Get emergency medical help if you have signs of an allergic reaction (hives, itching, anxiety, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • pain, swelling, bruising, redness, oozing, or skin changes where the injection was given;
  • a light-headed feeling, like you might pass out;
  • unusual changes in mood or behavior (feeling hopeless, anxious, nervous, irritable, or depressed);
  • thoughts about suicide or hurting yourself;
  • easy bruising, unusual bleeding;
  • a seizure;
  • heart problems --swelling, rapid weight gain, feeling short of breath, rapid heartbeats, chest pain spreading to your jaw or shoulder, nausea, sweating;
  • liver problems --nausea, loss of appetite, tiredness, confusion, easy bruising or bleeding, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes);
  • signs of infection --fever, chills, cough with mucus, bloody diarrhea, pain or burning when you urinate; or
  • thyroid problems --mood swings, trouble sleeping, tiredness, hunger, diarrhea, pounding heartbeats, muscle weakness, sweating, dry skin, thinning hair, menstrual changes, weight changes, puffiness in your face, feeling more sensitive to hot or cold temperatures.

Common side effects may include:

  • depression;
  • abnormal liver function tests;
  • stomach pain; or
  • flu symptoms --fever, chills, tiredness, muscle aches.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect interferon beta-1a?

Other drugs may affect interferon beta-1a, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about interferon beta-1a.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 7.01. Revision date: 7/22/2019.

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