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acetaminophen (injection)

Pronunciation: a SEET a MIN oh FEN

Brand: Ofirmev

What is the most important information I should know about acetaminophen injection?

Call your doctor at once if you have nausea, vomiting, upper stomach pain, and yellowing of your skin or eyes.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. Call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

What is acetaminophen injection?

Acetaminophen injection is used to treat pain in adults and children at least 2 years old. For moderate to severe pain, acetaminophen is sometimes given with opioid pain medicine.

Acetaminophen injection may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using acetaminophen injection?

You should not be treated with acetaminophen if you are allergic to it or if you have severe liver disease.

Tell your doctor if you have ever had:

  • bleeding problems;
  • liver disease, cirrhosis, alcoholism, or more than 3 alcoholic beverages per day;
  • kidney disease; or
  • if you've recently been sick with vomiting or diarrhea;
  • if you are malnourished.

Tell your doctor if you are pregnant or breastfeeding.

Pregnancy may be less likely to occur while the mother or the father is using this medicine.

How is acetaminophen injection given?

Acetaminophen is injected into a vein by a healthcare provider, usually once every 4 to 6 hours.

Doses are based on weight in people who weigh under 110 pounds (50 kilograms). If you use this medicine long term, your dose may change if you gain or lose weight.

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal.

Overdose symptoms include vomiting, stomach pain, and yellowing of your skin or eyes.

What should I avoid while using acetaminophen injection?

Avoid using other medicines that may contain acetaminophen (sometimes abbreviated as APAP).

Drinking alcohol may increase your risk of liver damage.

What are the possible side effects of acetaminophen injection?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal, even if you took acetaminophen in the past and had no reaction. Tell your caregivers or call your doctor if you have skin redness or a rash that spreads and causes blistering and peeling.

Stop using acetaminophen and call your doctor at once if you have:

  • fever, cough, chest pain, trouble breathing; or
  • liver problems --nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • cough, breathing problems;
  • nausea, vomiting;
  • constipation;
  • agitation;
  • itching;
  • headache; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetaminophen injection?

Tell your doctor if you also use a blood thinner (warfarin, Coumadin, Jantoven)

Other drugs may affect acetaminophen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2021 Cerner Multum, Inc. Version: 4.01. Revision date: 7/14/2021.

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